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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XV.k Path: Desquamative interstitial pneumonia (DIP-pattern)

2
Last update : 06/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Desquamative interstitial pneumonia.
Histopathology 2011 Mar;58;509-16 2011 Mar
Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet amiodarone therapy.
Clinical research in cardiology : official journal of the German Cardiac Society 2008 Dec;97;917-20 2008 Dec
Histiocytic lesions and proliferations in the lung.
Seminars in diagnostic pathology 2007 Aug;24;162-82 2007 Aug

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