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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XVI.s Imaging: An area or areas of involvement with high attenuation numbers or metallic density

3
Last update : 30/03/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

An enlarged heart with hyperdense consolidation.
The Netherlands journal of medicine 2013;71;317, 321 2013
HRCT findings of amiodarone pulmonary toxicity: clinical and radiologic regression.
Journal of cardiovascular pharmacology and therapeutics 2001 Jul;6;307-11 2001 Jul
Focal lung disease: CT and high-resolution CT applications.
Radiographics : a review publication of the Radiological Society of North America, Inc 1994 Jan;14;169-81; quiz 183-4 1994 Jan
The value of computed tomography in the diagnosis of amiodarone-induced pulmonary toxicity.
Clinical radiology 1989 Nov;40;564-7 1989 Nov
CT demonstration of high attenuation pleural-parenchymal lesions due to amiodarone therapy.
Journal of computer assisted tomography 1987;11;160-2 1987

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