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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Amiodarone
5
XVI.s
Imaging: An area or areas of involvement with high attenuation numbers or metallic density
3
Last update :
30/03/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
Excipients-Vehicle-Preservatives (of drugs)
Thyroid hormones (exogenous)
Publications
An enlarged heart with hyperdense consolidation.
HRCT findings of amiodarone pulmonary toxicity: clinical and radiologic regression.
Focal lung disease: CT and high-resolution CT applications.
The value of computed tomography in the diagnosis of amiodarone-induced pulmonary toxicity.
CT demonstration of high attenuation pleural-parenchymal lesions due to amiodarone therapy.