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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Amiodarone
5
XI.f
Bluish, pseudocyanotic skin discoloration
1
Last update :
02/01/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
Excipients-Vehicle-Preservatives (of drugs)
Thyroid hormones (exogenous)
Publications
Amiodarone induced "Blue man syndrome"; an unusual presentation.
Blue Woman Syndrome and Thyrotoxicosis in a Patient on Amiodarone.
[The "blue man"].
Amiodarone-induced facial pigmentation.
Pulmonary masses in a patient with blue-gray cutaneous hyperpigmentation.
Images in cardiovascular medicine. The blue man: amiodarone-induced skin discoloration.
[The face in not only coloured by blue blood].
[What is your diagnosis? Pseudocyanosis due to amiodarone].
A case of pseudocyanotic coloring of skin after prolonged use of amiodarone.
Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation.