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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 11/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Diffuse alveolar hemorrhage and acute eosinophilic pneumonia: A rare form of amiodarone pulmonary toxicity diagnosed by bronchoalveolar lavage.
Journal of cardiology cases 2023 Mar;27;93-96 2023 Mar
Amiodarone and diffuse alveolar hemorrhage.
Advances in respiratory medicine 2020;88;169-171 2020
Amiodarone-induced diffuse alveolar haemorrhage: a rare but potentially life-threatening complication of a commonly prescribed medication.
BMJ case reports 2019 Oct 25;12; 2019 Oct 25
Diffuse alveolar hemorrhage: how relevant is etiology?
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2019;36;47-52 2019
Trepopnea due to amiodarone-induced diffuse alveolar hemorrhage.
Respiratory care 2013 Feb;58;e11-3 2013 Feb
A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report.
Military medicine 2012 Jan;177;118-20 2012 Jan
Amiodarone-induced alveolar haemorrhage: a rare complication of a common medication.
Heart, lung & circulation 2010 Jul;19;435-7 2010 Jul
Acute alveolar hemorrhage and orthodeoxia induced by intravenous amiodarone.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 1999 May;47;61-3 1999 May

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