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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amiodarone

5

XIX.p BAL: Lamellar bodies in AM on EM

3
Last update : 24/12/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dronedarone
2
Excipients-Vehicle-Preservatives (of drugs)
5
Thyroid hormones (exogenous)
1

Publications

Amiodarone-induced pulmonary toxicity with an excellent response to treatment: A case report.
Respiratory medicine case reports 2020;29;100974 2020
Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry.
Annals of diagnostic pathology 1997 Oct;1;47-56 1997 Oct

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