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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Amphotericin B (infusion)

3

II.a Pulmonary edema, noncardiogenic (NCPE)

2
Last update : 06/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Amphotericin B Associated Pulmonary Complications in Chronic Granulomatous Disease Patients.
Pediatric blood & cancer 2016 Oct;63;1871-2 2016 Oct
Pulmonary reactions during treatment with amphotericin B: review of published cases and guidelines for management.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001 Oct 01;33;E75-82 2001 Oct 01
Safety and toxicity of amphotericin B in glucose 5% or intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study.
BMJ (Clinical research ed.) 1998 Aug 08;317;379-84 1998 Aug 08
Life-threatening adverse event after amphotericin B lipid complex treatment in a patient treated previously with amphotericin B deoxycholate.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998 Apr;26;1016 1998 Apr
Cardiopulmonary toxicity after liposomal amphotericin B infusion.
Annals of internal medicine 1991 Apr 15;114;664-6 1991 Apr 15

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