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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Melphalan

3

I.v Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

2
Last update : 29/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Busulfan + Melphalan regimen
1

Publications

Prospective evaluation of pulmonary function in cancer patients treated with total body irradiation, high-dose melphalan, and autologous hematopoietic stem cell transplantation.
International journal of radiation oncology, biology, physics 1990 Sep;19;743-9 1990 Sep

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