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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Minocycline

4

X.d Lupus - Lupus syndrome (see also Vd)

2
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antibiotics
5
Doxycycline
1
Minocycline (topical, transdermal)
1
Tetracycline
1

Publications

Do selected drugs increase the risk of lupus? A matched case-control study.
British journal of clinical pharmacology 2010 Oct;70;588-96 2010 Oct
Why minocycline can cause systemic lupus - a hypothesis and suggestions for therapeutic interventions based on it.
Medical hypotheses 2004;63;31-4 2004
Minocycline induced lupus: case series in the West of Scotland.
The Journal of rheumatology 2001 May;28;1004-6 2001 May
Minocycline-induced lupus: clinical features and response to rechallenge.
Rheumatology (Oxford, England) 2001 Mar;40;329-35 2001 Mar
Coexistent minocycline-induced systemic lupus erythematosus and autoimmune hepatitis.
Seminars in arthritis and rheumatism 1998 Dec;28;187-92 1998 Dec
Comparative safety of tetracycline, minocycline, and doxycycline.
Archives of dermatology 1997 Oct;133;1224-30 1997 Oct

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