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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Naproxen

2

X.a DRES syndrome - DRESS-like reaction

1
Last update : 06/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
5

Publications

Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement.
Radiology case reports 2020 Nov;15;2178-2182 2020 Nov
DRESS-syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpevirus 6 in an 11-year-old Caucasian boy.
Journal of clinical pharmacy and therapeutics 2010 Jun;35;365-70 2010 Jun
Hypersensitivity reactions to non-steroidal anti-inflammatory drugs.
Current drug metabolism 2009 Nov;10;971-80 2009 Nov
Nonsteroidal anti-inflammatory drug hypersensitivity syndrome. A multicenter study. I. Clinical findings and in vitro diagnosis.
Journal of investigational allergology & clinical immunology 2009;19;355-69 2009

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