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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Naproxen

2

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

2
Last update : 05/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
5

Publications

An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities.
Chest 2021 May;159;e325-e329 2021 May
Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement.
Radiology case reports 2020 Nov;15;2178-2182 2020 Nov
Naproxen and the occurrence of eosinophilic pneumonia.
American family physician 1993 Nov 01;48;1023 1993 Nov 01
Nonsteroidal anti-inflammatory drug-associated pulmonary infiltrates with eosinophilia. Review of the literature and Food and Drug Administration Adverse Drug Reaction reports.
Archives of internal medicine 1992 Jul;152;1521-4 1992 Jul
Pulmonary infiltrates with eosinophilia due to naproxen.
Japanese journal of medicine 1991;30;32-4 1991
Pulmonary eosinophilia associated with naproxen therapy.
Journal of the Royal Society of Medicine 1987 Feb;80;120-1 1987 Feb
Pulmonary infiltrates and eosinophilia associated with naproxen.
British journal of rheumatology 1985 Aug;24;302-3 1985 Aug
Naproxen and pneumonitis.
JAMA 1984 Oct 12;252;1853 1984 Oct 12
Pulmonary infiltrates associated with naproxen.
JAMA 1984 Jan 06;251;65-6 1984 Jan 06
Pulmonary infiltrates with eosinophilia due to naproxen.
Chest 1983 Feb;83;280-2 1983 Feb

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