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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Procainamide

4

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

2
Last update : 03/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Drug-induced lupus erythematosus.
Autoimmunity 2005 Nov;38;507-18 2005 Nov
Drug-induced lupus.
Toxicology 2005 Apr 15;209;135-47 2005 Apr 15
[Procainamide-induced lupus in a patient with bilateral pleural effusion].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 1998 Jun;36;535-40 1998 Jun
Cardiac tamponade associated with drug-induced systemic lupus erythematosus.
Critical care medicine 1989 Sep;17;961-2 1989 Sep
Procainamide-induced lupus erythematosus-like syndrome in relation to acetylator phenotype and plasma levels of procainamide.
Acta medica Scandinavica 1979;206;245-51 1979
Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid.
Chest 1978 Jun;73;875-6 1978 Jun
Pericardial tamponade. A presenting manifestation of procainamide-induced lupus erythematosus.
The American journal of medicine 1975 Apr;58;581-5 1975 Apr
Procainamide induction of a systemic lupus erythematosus-like syndrome. Presentation of six cases, review of the literature, and analysis and followup of reported cases.
Medicine 1969 May;48;217-28 1969 May
LUPUS-LIKE ILLNESS PRECIPITATED BY PROCAINAMIDE HYDROCHLORIDE.
JAMA 1965 May 10;192;444-7 1965 May 10
Procainamide-induced lupus erythematosus.
The New England journal of medicine 1962 Dec 27;267;1357-8 1962 Dec 27

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