Pneumotox » Drug » Protamine » VI.i - Acute pulmonary hypertension

Protamine

Can cause catastrophic hemodynamic instability. Occurs electively in the intra/perioperative period, during heparin reversal

Last update : 13/09/2012

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment