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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Sirolimus
4
I.d
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
2
Last update :
09/07/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
Publications
Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.
Patterns of pulmonary complications associated with sirolimus.
BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus.
Sirolimus-associated pulmonary toxicity.
Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.
Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.
Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients.