Pneumotox » Drug » MTOR inhibitors

MTOR inhibitors

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Mammalian-TOR inhibitors. Reviews and management at PMID 22689175, 23852656, 24517115, 25580277, 26836903

Last update : 01/11/2018

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

3

I.b Pneumonitis (ILD)

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1

I.l Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

1

I.m ILD with a granulomatous component

1

I.p Fatal pneumonitis (ILD)

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2

VI.d Pulmonary vasculitis or capillaritis

1

VIII.a Angioedema (may cause UAO, asphyxia and death)

2

XI.w Cavitation/necrosis of lung tumor or metastases

1

XV.g Path: Alveolar hemorrhage (see also IIIa)

1

XVI.bf Imaging: Tumoral cavitation

1

XVII.a Respiratory tract infection incl. pneumonia

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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