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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Streptokinase

2

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3

Publications

Alveolar Hemorrhage Following Thrombolytic Therapy for Acute Myocardial Infarction: Two Case Reports and Literature Review.
Open access emergency medicine : OAEM 2021;13;399-405 2021
Pulmonary haemorrhage following thrombolysis with streptokinase in myocardial infarction.
BMJ case reports 2020 Jan 23;13; 2020 Jan 23
[Alveolar hemorrhage as a complication of thrombolytic therapy].
Medicina 2011;71;547-9 2011
Diffuse alveolar hemorrhage following thrombolytic therapy for acute myocardial infarction.
Respiration; international review of thoracic diseases 2000;67;445-8 2000
Diffuse pulmonary hemorrhage after fibrinolytic therapy for acute myocardial infarction.
International journal of cardiology 1998 Jan 05;63;95-7 1998 Jan 05
Diffuse pulmonary hemorrhage after streptokinase administration for acute myocardial infarction.
Pharmacotherapy 1997;17;390-4 1997
Spontaneous pulmonary hemorrhage after thrombolytic therapy for acute myocardial infarction.
Chest 1994 Nov;106;1622-4 1994 Nov
Pulmonary hemorrhage following intravenous streptokinase for acute myocardial infarction.
International journal of cardiology 1990 Dec;29;387-90 1990 Dec

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