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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gefitinib

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 01/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Tyrosine kinase inhibitors (EGFR) TKI
5

Publications

[A case of alveolar hemorrhage caused by gefitinib].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2011 Jul;49;506-10 2011 Jul
Acute lung injury as a possible adverse drug reaction related to gefitinib.
The European respiratory journal 2003 Jul;22;179-81 2003 Jul

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