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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nafazoline

1

II.a Pulmonary edema, noncardiogenic (NCPE)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary edema and prolonged awakening after nasal naphazoline application in a transspenoidal hypophysectomy patient.
Journal of neurosurgical anesthesiology 2010 Jul;22;269 2010 Jul
Acute pulmonary edema associated with naphazoline ingestion.
Clinical toxicology (Philadelphia, Pa.) 2008 Mar;46;254-6 2008 Mar
[Cardiac arrest and secondary pulmonary oedema following accidental intramucosal injection of naphazoline in an adult].
Annales francaises d'anesthesie et de reanimation 2003 May;22;477-80 2003 May
Prolonged awakening and pulmonary edema after general anesthesia and naphazoline application in an infant.
Anesthesia and analgesia 2001 Nov;93;1162-4, table of contents 2001 Nov

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