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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 20/01/2012
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
MTOR inhibitors
5

Publications

Fatal case of cryptogenic organizing pneumonia associated with everolimus.
Annals of Saudi medicine 2014;34;437-9 2014
Everolimus-related pulmonary toxicity in heart transplant recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 Jul;27;797-800 2008 Jul
Case report of a kidney transplant recipient converted to everolimus due to malignancy: resolution of bronchiolitis obliterans organizing pneumonia without everolimus discontinuation.
Transplantation proceedings 2007 Apr;39;594-5 2007 Apr

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