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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
MTOR inhibitors
5

Publications

Everolimus-associated alveolar hemorrage relapse after drug discontinuation in a kidney transplant recipient.
Journal of nephrology 2022 May;35;1275-1278 2022 May
Everolimus-induced severe pulmonary toxicity with diffuse alveolar hemorrhage.
Annals of the American Thoracic Society 2013 Dec;10;727-9 2013 Dec
Fatal acute pulmonary injury associated with everolimus.
The Annals of pharmacotherapy 2012 Mar;46;e7 2012 Mar
Diffuse alveolar hemorrhage induced by everolimus.
Chest 2010 Feb;137;456-9 2010 Feb

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