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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Everolimus

5

I.v Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

2
Last update : 04/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

Prospective Study of Drug-induced Interstitial Lung Disease in Advanced Breast Cancer Patients Receiving Everolimus Plus Exemestane.
Targeted oncology 2019 Aug;14;441-451 2019 Aug
Changes in the diffusion capacity for carbon monoxide and the development of non-infectious pneumonitis in patients with metastatic renal cell carcinoma treated with everolimus.
Anticancer research 2014 Oct;34;5723-8 2014 Oct

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