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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Erlotinib

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 31/05/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Tyrosine kinase inhibitors (EGFR) TKI
5

Publications

Fatal interstitial lung disease associated with high erlotinib and metabolite levels. A case report and a review of the literature.
Lung cancer (Amsterdam, Netherlands) 2012 Mar;75;391-7 2012 Mar
Erlotinib-induced acute interstitial lung disease associated with extreme elevation of the plasma concentration in an elderly non-small-cell lung cancer patient.
Journal of cancer research and therapeutics 2012;8;154-6 2012
Radiation recall pneumonitis caused by erlotinib after palliative definitive radiotherapy.
Onkologie 2012;35;191-4 2012
New-onset acute interstitial lung disease after treatment with erlotinib in a patient with metastatic squamous cell carcinoma of the lung.
American journal of therapeutics 2011 Jan;18;e19-21 2011 Jan
Interstitial lung disease associated to erlotinib treatment: a case report.
Cases journal 2010 Feb 12;3;59 2010 Feb 12
Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008 Dec;3;1439-45 2008 Dec

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