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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Oxygen (dioxygen, O2)

4

II.b ARDS - Acute lung injury

3
Last update : 29/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Targeting normoxemia in acute respiratory distress syndrome may cause worse short-term outcomes because of oxygen toxicity.
Annals of the American Thoracic Society 2014 Nov;11;1449-53 2014 Nov
Oxygen toxicity.
Paediatric respiratory reviews 2014 Jun;15;120-3 2014 Jun
[Acute respiratory distress syndrome after prolonged hyperbaric oxygen therapy: a case of pulmonary oxygen toxicity?].
Annales francaises d'anesthesie et de reanimation 2001 Jun;20;559-62 2001 Jun
Postoperative acute respiratory distress syndrome. A complication of amiodarone associated with 100 percent oxygen ventilation.
Chest 1992 Sep;102;980-1 1992 Sep
Oxygen-exacerbated bleomycin pulmonary toxicity.
Mayo Clinic proceedings 1991 Feb;66;173-8 1991 Feb
Pulmonary oxygen toxicity.
Chest 1985 Dec;88;900-5 1985 Dec
Oxygen pneumonitis in man., Light- and electron-microscopic morphometric studies.
Chest 1972 Aug;62;162-9 1972 Aug
Pulmonary oxygen toxicity: a review.
Pharmacological reviews 1971 Jun;23;37-133 1971 Jun
Oxygen toxicity in man. A prospective study in patients with irreversible brain damage.
The New England journal of medicine 1970 Dec 31;283;1478-84 1970 Dec 31
Case records of the Massachusetts General Hospital. Case 7-1967.
The New England journal of medicine 1967 Feb 16;276;401-11 1967 Feb 16
Pulmonary lesions associated with oxygen therapy and artificial ventilation.
The New England journal of medicine 1967 Feb 16;276;368-74 1967 Feb 16

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