Like NO, molecular oxygen or dioxygen or O2 is listed as a drug. Oxygen can cause lung damage known as hyperoxic lung injury (HLI/HOLI). Oxygen can also trigger or potentiate amiodarone-, chemotherapy- and radiation-induced lung injury. Elevated FIO2 above 0.6 for >24hr may cause HLI/HOLI. See PMID: 21994818, 22804568, 23271823. See also PMID 4936578, 4948324, 6247652, 9887137, 15485081, 20430708, 25314313. And an interesting study in pigs at PMID 10924582

Last update : 26/01/2017