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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Oxygen (dioxygen, O2)

4

I.l Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

2
Last update : 08/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Oxygen toxicity.
Paediatric respiratory reviews 2014 Jun;15;120-3 2014 Jun
Hyperoxia-derived lung damage in preterm infants.
Seminars in fetal & neonatal medicine 2010 Aug;15;223-9 2010 Aug
Oxygen pneumonitis in man., Light- and electron-microscopic morphometric studies.
Chest 1972 Aug;62;162-9 1972 Aug
Pulmonary lesions associated with oxygen therapy and artificial ventilation.
The New England journal of medicine 1967 Feb 16;276;368-74 1967 Feb 16

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