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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Busulfan
5
I.g
Pulmonary fibrosis
3
Last update :
10/07/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Busulfan + Melphalan regimen
Publications
High-dose busulfan and the risk of pulmonary mortality after autologous stem cell transplant.
25-year study of lung fibrosis following carmustine therapy for brain tumor in childhood.
[Busulfan-induced pneumopathy].
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced pulmonary fibrosis.
Busulfan lung.
Fatal radiation pneumonia following subclinical busulfin injury.
Busulfan lung. Report of two cases and review of the literature.
Interstitial pulmonary fibrosis following busulfan therapy.