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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT)

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

3
Last update : 29/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics.
Haematologica 2018 Dec;103;2109-2115 2018 Dec
Late-onset noninfectious pulmonary complications in adult allogeneic hematopoietic cell transplant recipients.
Transplantation 2011 Apr 15;91;798-803 2011 Apr 15
Outcome of alveolar hemorrhage in hematopoietic stem cell transplant recipients.
Bone marrow transplantation 2007 Jul;40;71-8 2007 Jul
Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: treatment with recombinant factor VIIa.
Chest 2003 Dec;124;2400-3 2003 Dec
Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings.
Radiographics : a review publication of the Radiological Society of North America, Inc 1997;17;1359-71 1997
Diffuse alveolar haemorrhage associated with microangiopathy after allogeneic bone marrow transplantation.
Bone marrow transplantation 1995 Jun;15;863-7 1995 Jun

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