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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemicals

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 13/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aniline - Aminophenols
1
Caustic chemicals
3
Diacetyl (2,3-butanedione) flavoring agent
3
Gases
5
Hydrocarbons (petrochemicals: petroleum, petrolatum, paraffin, vaseline, naphta, jet fuel (kerosene), Diesel, gasoil), ointments, salad oil, variegated oils, butter). Aspirated
5
Laundry detergent pods
3
Nail polish remover
1
Nitric acid fumes
1
Nitrites - Nitrates (oral - inhaled ('Poppers'))
3
Nitrobenzene
3
Potassium permanganate
1
Trichloroethylene
1

Publications

Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited.
Respiratory medicine 2012 Jul;106;1021-32 2012 Jul
Inhalant abuse: a case of hemoptysis associated with halogenated hydrocarbons abuse.
Pediatric emergency care 2009 Nov;25;754-7 2009 Nov
Alveolar hemorrhage in anti-basement membrane antibody disease: a series of 28 cases.
Medicine 2007 May;86;181-193 2007 May
[Alveolar hemorrhage caused by exposure to pesticides].
Pneumonologia i alergologia polska 2001;69;206-10 2001
Pulmonary hemorrhage due to inhalation of vapor containing pyromellitic dianhydride.
Chest 1993 Aug;104;644-5 1993 Aug

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