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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nilotinib

2

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 04/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bosutinib
2
Dasatinib
4
Imatinib
3
Ponatinib
2

Publications

Severe dyspnoea in a patient with chronic myelogenous leukaemia on a tyrosine kinase inhibitor.
Thorax 2015 Jul;70;701-4 2015 Jul
Pleural effusion: a rare side effect of nilotinib-a case report.
Case reports in medicine 2014;2014;203939 2014
Occurrence and current management of side effects in chronic myeloid leukemia patients treated frontline with tyrosine kinase inhibitors.
Leukemia research 2013 Jun;37;713-20 2013 Jun
Successful treatment of nilotinib-induced pleural effusion with prednisone.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2013 Jun;19;175-7 2013 Jun

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