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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Cyanoacrylate (N-butyl-2-cyanoacrylate-Histoacryl)
4
XVIII.g
Eye-catcher: Cement (pulmonary) embolism
2
Last update :
28/03/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Cement (bone cement, kyphoplasty, vertebroplasty)
Publications
Severe respiratory failure due to embolization of cyanoacrylate sclerosant.
Acute pulmonary embolism following -butyl-cyanoacrylate endoscopic injection sclerotherapy.
Cyanoacrylate in the treatment of gastric varices complicated by multiple pulmonary emboli.
Fatal N-butyl-2-cyanoacrylate pulmonary embolism after sclerotherapy for variceal bleeding.