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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dextran

2

II.a Pulmonary edema, noncardiogenic (NCPE)

1
Last update : 30/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Delayed resolution of negative pressure pulmonary edema associated with low-molecular-weight dextran after microsurgery--a case report.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 2005 Sep;43;187-91 2005 Sep
A 52-year-old man with pulmonary edema following large-volume transfusion.
Chest 2004 Apr;125;1556-60 2004 Apr
Dextran syndrome. Acute hypotension, noncardiogenic pulmonary edema, anemia, and coagulopathy following hysteroscopic surgery using 32% dextran 70.
Chest 1997 Feb;111;513-8 1997 Feb
Hyskon-induced pulmonary edema.
Surgery, gynecology & obstetrics 1993 Dec;177;561-4 1993 Dec
Dextran 70 embolization. Another cause of pulmonary hemorrhage, coagulopathy, and rhabdomyolysis.
Chest 1993 Aug;104;631-3 1993 Aug
Noncardiogenic pulmonary edema: a complication of operative hysteroscopy.
Fertility and sterility 1987 Sep;48;497-9 1987 Sep
Noncardiogenic pulmonary edema secondary to intrauterine instillation of 32% dextran 70.
Fertility and sterility 1985 Mar;43;479-80 1985 Mar
Dextran 40: another cause of drug-induced noncardiogenic pulmonary edema.
Chest 1975 Sep;68;376-7 1975 Sep

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