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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
XV.aq
Path: Resin (Kayexalate-Sevelamer) lung
Last update :
01/01/1970
Causative drugs
2
Kayexalate
II.b
II - Pulmonary edema - Acute lung injury - ARDS
II.b - ARDS - Acute lung injury
IV.i
IV - Airway involvement
IV.i - Foreign body aspiration bronchiolitis
XI.g
XI - Miscellaneous
XI.g - Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)
XV.aq
XV - Pathology
XV.aq - Path: Resin (Kayexalate-Sevelamer) lung
1
Sevelamer
IV.i
IV - Airway involvement
IV.i - Foreign body aspiration bronchiolitis
XV.aq
XV - Pathology
XV.aq - Path: Resin (Kayexalate-Sevelamer) lung
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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