Pneumotox » Drug » Doxorubicin - Adriamycin

Doxorubicin - Adriamycin

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Last update : 05/07/2014

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1

I.g Pulmonary fibrosis

1

I.ad Radiation recall pneumonitis

1

II.b ARDS - Acute lung injury

1

XII.a Left or biventricular dysfunction/failure

2

XII.f Cardiomyopathy (acute, subacute, chronic)

3

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1

XII.s Heart block (bundle branch- or AV-)

1

XII.ai Cardiotoxicity

3

XII.bb Endocardial fibroelastosis

1

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1

XXIV.j Veterinary: Cardiotoxicity

1

Diagnosing DIRD

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Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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