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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
VIII.ao
Laryngeal injury
Last update :
01/01/1970
Causative drugs
2
Amikacin (inhaled-, liposomal-)
I.b
I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
I.d
I - Interstitial/parenchymal lung disease
I.d - Organizing pneumonia pattern (an area or areas of consolidation on imaging)
I.ao
I - Interstitial/parenchymal lung disease
I.ao - Pulmonary infiltrates
III.c
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.c - Hemoptysis
IV.a
IV - Airway involvement
IV.a - Bronchospasm - Wheezing - Asthma
IV.f
IV - Airway involvement
IV.f - Severe or catastrophic bronchospasm or asthma attack (can be fatal)
VIII.h
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.h - Vocal cord dysfunction, adduction, closure, injury
VIII.j
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.j - Laryngeal disorder-Laryngeal nerve palsy (dysphonia, hoarseness)
VIII.ao
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ao - Laryngeal injury
XV.c
XV - Pathology
XV.c - Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)
1
Antibiotics, inhaled
IV.a
IV - Airway involvement
IV.a - Bronchospasm - Wheezing - Asthma
VIII.h
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.h - Vocal cord dysfunction, adduction, closure, injury
VIII.t
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.t - Vocal cord paresis/paralysis
VIII.ao
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ao - Laryngeal injury
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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