Pneumotox » Drug

TGN1412

TGN1412 a.k.a. CD28 super MAb is a superagonist anti-CD28 monoclonal antibody. ARDS developed shortly after infusion in six volunteers. The drug has been recalled

Last update : 13/10/2014

II.b ARDS - Acute lung injury

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

TGN1412

II.b ARDS - Acute lung injury