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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Tetrachloroethylene - Perchlorethylene (C2Cl4)
2
Last update :
06/03/2018
I - Interstitial/parenchymal lung disease
I.d
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
1
I.an
Hypersensitivity pneumonitis pattern
1
XI - Miscellaneous
XI.r
Death following exposure or poisoning
1
XI.s
Sniffing death - Death from inhalation of compound
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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