Pneumotox » Drug

Heparin

Review on heparin-induced thrombocytopenia and its pulmonary complications, a major complication of therapy with heparin, available at PMID 24319250, 16928996

Last update : 11/08/2015

II.b ARDS - Acute lung injury

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

V.e Hemothorax - Serosanguineous pleural effusion

V.n Hemopericardium - Bloody pericardial effusion

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

VII.g Hemomediastinum - Mediastinal hematoma

VIII.b Hematoma of/around central airway wall potentially causing UAO

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

XI.k Esophageal hematoma (may cause chest pain and/or tracheal compression)

XII.u Left-sided intracavitary thrombosis

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France