Pneumotox » Drug » Amphotericin B (infusion)

Amphotericin B (infusion)

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Last update : 11/08/2021

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

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II.a Pulmonary edema, noncardiogenic (NCPE)

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II.b ARDS - Acute lung injury

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IV.a Bronchospasm - Wheezing - Asthma

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VI.e Fat/oil embolism - The FES embolism syndrome

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VIII.c Upper airway obstruction other than angioedema or hematoma

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X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

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X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

2

X.r Fluid retention

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XI.b Chest pain (acute or subacute), lone or prominent

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XII.m Cardiac- cardiorespiratory/pulmonary arrest

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XV.ae Path: Lipid/fat embolism (see also VIe)

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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