Pneumotox » Drug » Methylprednisolone

Methylprednisolone

See also under 'corticosteroids' for AEs common to all corticosteroid drugs including opportunistic pulmonary infections. Hypersensitivity may be due to lactose in patients allergic to milk (PMID 25017540)

Last update : 21/04/2015

IV.a Bronchospasm - Wheezing - Asthma

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

VIII.a Angioedema (may cause UAO, asphyxia and death)

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

XII.m Cardiac- cardiorespiratory/pulmonary arrest

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website