Pneumotox » Drug » Gold (chrysotherapy)

Gold (chrysotherapy)

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Gold salts including aurothiolamate, auranofin, aurothioglucose, gold sodium thiomalate

Last update : 19/01/2016

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2

I.b Pneumonitis (ILD)

3

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

2

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1

I.g Pulmonary fibrosis

2

I.h Subclinical pulmonary infiltrates/ILD

1

IV.c Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

1

IV.n Obstructive airway dysfunction (see also IVc, XVx)

1

XV.a Path: NSIP-cellular pattern (see also Ia, Ib)

2

XIX.a BAL: An excess proportion of lymphocytes

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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