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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Gold (chrysotherapy)
3
I.g
Pulmonary fibrosis
2
Last update :
17/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aurothiopropanosulfonate
Publications
[Gold salt alveolitis in 3 patients with rheumatoid arthritis].
[Fatal diffuse alveolar damage after gold medication].
[Fatal pulmonary fibrosis caused by gold therapy?].
Reversal of progressive, life-threatening gold hypersensitivity pneumonitis by corticosteroids.
Pulmonary fibrosis associated with hypersensitivity to gold salts.