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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Ergots, ergot alkaloids, ergolines
4
XVI.ap
Imaging: Pleural thickening w/wo rounded atelectasis
2
Last update :
25/05/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bromocriptine
Cabergoline
Dihydroergocristine
Dihydroergocryptine
Dihydroergotamine
Ergonovine
Ergotamine
Methysergide
Nicergoline
Pergolide
Publications
Pleuropulmonary changes induced by ergoline drugs.
Pleural and pericardial fibrosis after ergotamine therapy.
Pleural thickening caused by Sansert and Ergotrate in the treatment of migraine.