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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Salbutamol - Albuterol

3

XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

1

v.i.z. lactic acidosis

Last update : 09/01/2013
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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Publications

Metabolic acidosis due to inhaled salbutamol toxicity: A hazardous side effect complicating management of suspected cases of acute severe asthma.
Medical journal, Armed Forces India 2012 Jul;68;242-4 2012 Jul
Salbutamol: beware of the paradox!
BMJ case reports 2010 Sep 29;2010; 2010 Sep 29
Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.
Emergency medicine journal : EMJ 2005 Jun;22;404-8 2005 Jun
A rare side-effect of intravenous salbutamol.
Anaesthesia 2004 Feb;59;196-7 2004 Feb
A paradoxical effect of bronchodilators.
Chest 1997 Jun;111;1766-7 1997 Jun

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