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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Levamisole

4

X.ak Dual MPO-/PR3-ANCA systemic disease/vasculitis/pseudovasculitis

1
Last update : 19/09/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
5
Cocaine
5
Crack cocaine
5
Levamisole-adulterated/tainted cocaine
5

Publications

Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.
BMJ case reports 2018 Sep 19;2018; 2018 Sep 19
Levamisole-contaminated cocaine: a hairy affair.
BMJ case reports 2015 Aug 26;2015; 2015 Aug 26
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Current opinion in rheumatology 2014 Jan;26;42-9 2014 Jan

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