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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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MTOR inhibitors

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 01/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Everolimus
5
Ridaforolimus
2
Sirolimus
4
Temsirolimus
2
Zotarolimus
1

Publications

Everolimus-induced severe pulmonary toxicity with diffuse alveolar hemorrhage.
Annals of the American Thoracic Society 2013 Dec;10;727-9 2013 Dec
Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.
Diagnostic pathology 2012 Mar 14;7;25 2012 Mar 14
Fatal acute pulmonary injury associated with everolimus.
The Annals of pharmacotherapy 2012 Mar;46;e7 2012 Mar
Persistent dyspnea in a 59-year-old woman receiving immunosuppressants.
Chest 2011 Sep;140;818-822 2011 Sep
Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care.
Journal of critical care 2010 Jun;25;230-5 2010 Jun
Diffuse alveolar hemorrhage induced by everolimus.
Chest 2010 Feb;137;456-9 2010 Feb
Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma.
American journal of respiratory and critical care medicine 2010 Aug 01;182;396-403 2010 Aug 01
Fatal diffuse alveolar hemorrhage associated with sirolimus after allogeneic hematopoietic cell transplantation.
Bone marrow transplantation 2010 Aug;45;1363-4 2010 Aug
Sirolimus-induced alveolar hemorrhage.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Jun;26;652-7 2007 Jun

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