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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Warfarin

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Cocaine
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4

Publications

Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation.
Case reports in medicine 2019;2019;4917856 2019
Diffuse Alveolar Hemorrhage Associated with Warfarin Therapy.
Case reports in medicine 2015;2015;350532 2015
A life-threatening complication of warfarin therapy in ED: diffuse alveolar hemorrhage.
The American journal of emergency medicine 2014 Jun;32;690.e3-4 2014 Jun
Successful management of warfarin-exacerbated diffuse alveolar hemorrhage using an extracorporeal membrane oxygenation.
Multidisciplinary respiratory medicine 2013 Feb 27;8;16 2013 Feb 27
Case records of the Massachusetts General Hospital. Case 1-2007. A 40-year-old woman with epistaxis, hematemesis, and altered mental status.
The New England journal of medicine 2007 Jan 11;356;174-82 2007 Jan 11
Diffuse alveolar hemorrhage secondary to superwarfarin ingestion.
Chest 1992 Oct;102;1301-2 1992 Oct

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