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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Warfarin

5

VIII.b Hematoma of/around central airway wall potentially causing UAO

2
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Cocaine
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4

Publications

Images in Clinical Medicine. Spontaneous Retropharyngeal Hematoma.
The New England journal of medicine 2016 Jan 21;374;e3 2016 Jan 21
Upper Airway Hematoma Secondary to Warfarin Therapy: A Systematic Review of Reported Cases.
North American journal of medical sciences 2015 Nov;7;494-502 2015 Nov
Spontaneous lingual and sublingual haematoma: a rare complication of warfarin use.
BMJ case reports 2014 Jul 09;2014; 2014 Jul 09
Lingual and sublingual hematoma causing upper airway obstruction.
The Journal of emergency medicine 2012 Dec;43;1075-6 2012 Dec
Warfarin-induced sublingual hematoma mimicking Ludwig angina: Conservative management of a potentially life-threatening condition.
Ear, nose, & throat journal 2011 Feb;90;E1 2011 Feb
Upper airway obstruction by epiglottis and arytenoids hematoma in a patient treated with warfarin sodium.
Auris, nasus, larynx 2010 Feb;37;114-6 2010 Feb
Spontaneous haematoma of the pharynx due to a rare drug interaction.
Hippokratia 2009 Jul;13;175-7 2009 Jul
Lingual haematoma: a rare complication of usual warfarin dose.
Emergency medicine journal : EMJ 2008 Jul;25;406 2008 Jul
Case of sublingual hematoma threatening airway obstruction.
Medical science monitor : international medical journal of experimental and clinical research 2003 Nov;9;CS95-7 2003 Nov
Upper airway obstruction secondary to warfarin-induced sublingual hematoma.
Archives of otolaryngology--head & neck surgery 1989 Jun;115;718-20 1989 Jun
Unusual complications in the course of anticoagulant therapy.
The American journal of medicine 1969 Mar;46;460-3 1969 Mar

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