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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

Trimethoprim-sulfamethoxazole induced eosinophilic pneumonia: A case report.
Respiratory medicine case reports 2022;37;101632 2022
Hypersensitivity pneumonitis induced by trimethoprim.
BMJ (Clinical research ed.) 1990 May 19;300;1344 1990 May 19
[Drug induced interstitial lung diseases after treatment with cotrimoxazole. 2 cases].
La Nouvelle presse medicale 1980 Sep 20;9;2347 1980 Sep 20

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