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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trimethoprim sulfamethoxazole (TMP-SMX)

3

XV.ct Path: Delayed alveolar injury with delayed epithelialization (DAIDE)

1
Last update : 12/02/2022
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfadoxine
1
Sulfamethoxypyridazine
1
Sulfamides - Sulfonamides
3
Sulfasalazine
3

Publications

ARDS With Pneumothorax in a Young Adult.
Chest 2022 Feb;161;e111-e116 2022 Feb
Trimethoprim-Sulfamethoxazole-associated Fulminant Respiratory Failure in Children and Young Adults.
American journal of respiratory and critical care medicine 2021 Apr 01;203;918-921 2021 Apr 01
A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury.
The American journal of pathology 2018 May;188;1149-1160 2018 May

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