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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dexfenfluramine

3

XII.b Valvular heart disease and/or dysfunction

2
Last update : 26/01/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
5
Amphetamine (and -derivatives)
3
Cocaine
5
Fenfluramine
3
Levamisole
4

Publications

Drug-induced valvular heart disease: an update.
Archives of cardiovascular diseases 2013 May;106;333-9 2013 May
Fenfluramine-like cardiovascular side-effects of benfluorex.
The European respiratory journal 2009 Mar;33;684-8 2009 Mar
Valvular heart disease associated with dexfenfluramine.
The New England journal of medicine 1997 Aug 28;337;636 1997 Aug 28

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