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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
XII.bj
Eosinophilic coronary (peri)-arteritis
Last update :
01/01/1970
Causative drugs
1
Loxoprofen
I.b
I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
I.c
I - Interstitial/parenchymal lung disease
I.c - Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
I.d
I - Interstitial/parenchymal lung disease
I.d - Organizing pneumonia pattern (an area or areas of consolidation on imaging)
IV.a
IV - Airway involvement
IV.a - Bronchospasm - Wheezing - Asthma
XII.ay
XII - Cardiovascular involvement / toxicity
XII.ay - Coronary (artery) vasculitis
XII.bj
XII - Cardiovascular involvement / toxicity
XII.bj - Eosinophilic coronary (peri)-arteritis
XV.cm
XV - Pathology
XV.cm - Path: Coronary vasculitis w/wo eosinophilia
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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